Chromosomal breaks during mitotic catastrophe trigger γH2AX–ATM–p53-mediated apoptosis

Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis.

Although the cause and outcome of mitotic catastrophe (MC) has been thoroughly investigated, precisely how the ensuing lethality is regulated during or following this process and what signals are involved remain unknown. Moreover, the mechanism of the decision of cell death modalities following MC is still not well characterised. We demonstrate here a crucial role of the γH2AX-ATM-p53 pathway i...

Publisher's Note: Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis. J. Cell Sci. doi: 10.1242/jcs.081612.

This Publisher’s Note updates and replaces the Expression of Concern (doi: 10.1242/jcs.205559) relating to the article ‘Chromosomal breaks during mitotic catastrophe trigger γH2AX–ATM–p53-mediated apoptosis’ by Gabriela Imreh, Helin Vakifahmetoglu Norberg, Stefan Imreh and Boris Zhivotovsky (2011). J. Cell Sci. 124, 2951-2963 (doi: 10.1242/jcs.081612). Concerns were raised regarding some of the...

Expression of Concern: Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis. Gabriela Imreh, Helin Vakifahmetoglu Norberg, Stefan Imreh, Boris Zhivotovsky. J. Cell Sci. doi: 10.1242/jcs.081612.

Curcumin affects components of the chromosomal passenger complex and induces mitotic catastrophe in apoptosis-resistant Bcr-Abl-expressing cells.

The Bcr-Abl oncoprotein plays a major role in the development and progression of chronic myeloid leukemia and is a determinant of chemotherapy resistance occurring during the blast crisis phase of the disease. The aim of this article was to investigate the possibility of combating the resistance to apoptosis caused by Bcr-Abl by inducing an alternative cell death process. As a model of chronic ...

The chromosomal passenger complex during mitotic progression